Endocrine Abstracts

Aim/objectives: To investigate relationships between thyroid function, antithyroperoxydase antibodies (ATPO), antithyroglobuline antibodies (ATG) and correlations with echographic pattern in Hashimoto thyroiditis and related diseases.Materials and methods: Diagnosis: i) ATPO >34 μ/ml=Hashimoto thyroiditis (HT); ii) ATPO=normal with high ATG=thyroiditis with only hyper-ATG (T-ATG). Thyroid function: TSH. Echographic patterns=10 (Peretianu, this C...

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease between 1–20 years.Material and method: i). Diagnostic: Hashimoto thyroiditis (HT): 1. antithyroperoxydase antibodies (ATPO), cut-off 34 ui/ml. 2. if ATPO=normal, thyroiditis was considered if high antithyroglobuline antibodies (T-ATG); 3. idiopathic mixedema (IM): hypothyroidism with no ATPO, no A...

Material and method: i). Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT) =1293, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG) =92, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis) =11, D. idiopathic myxedema (hypothyroidism, no A,B,C) =86; E. control=1219. 2. Statistical analysis: X2 test, z test.Results:...

Aim and Objectives: Is Hashimoto thyroiditis (HT) different from thyroiditis with only antithyroglobulin antibodies (T-ATG)?Material and method: i). Diagnosis: ATPO >34 ui/ml = HT; ATPO normal with high ATG (>34 ui/ml) =T-ATG. ii). Thyroid function: TSH. iii). Patients: HT=1293, T-ATG=92. iv). Statistical analysis: Student tα, linear correlation tests....

Objectives: To investigate how the immune associations (IA) may have significance for diagnosis or therapy in thyroiditis.Material and method: i) Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT)=1196, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG)=73, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis)=8, D. idiopathic myxedema (hypothyroidism, no A,B,C)=69; E. control=1...

Aim: To re-analyze the concept of echographic thyroid patterns (ETP) and clinical diagnostic in thyroidology, proposed 12 years ago.Materials and methods: i) Between 1996 and 2012, >25 000 thyroid ultrasound, linear probes, 7.5 MHz. ii) New description – 10 ETP: pattern 0, lack of thyroid; 1, marked hypoechogenous pseudonodular; 2, hypoecogen homogenous; 3, micronodular hypoechogenous; 4, macro (>10 mm; ±micro) nodular; 5, inhomogeneous...

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–17 years.Materials and methods: i) Diagnostic: Hashimoto’s thyroiditis (HT): a) antithyroperoxydase antibodies (ATPO) cut-off 34 IU/ml. b) If ATPO=normal, thyroiditis was considered if high antithyroglobuline antibodies (T-ATG). c) Idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, and no TRAB. ii) Patients: HT: 1196; T-ATG: 73; IM: 69. Women/me...

Introduction: Testosterone therapy in elderly is controversial, because of the effect on prostate. The old age itself is not a contraindication in the therapy of hypogonadism.Aim: We analyze the effect of 24 months of therapy with testosterone undecanoat depot (1000 mg/4 ml) (TUD) on the volume of the prostate (VP).Patients and method: The patients were 79 symptomatic hypogonadic men, with normal value of PSA (<4 g/l). The urol...

Introduction: Sorafenib, an orphan medication, is an oral protein kinase inhibitor, used in the treatment of hepatic, advanced renal and breast cancer, or metastatic iodine-refractary thyroid cancer. The drug also inhibits angiogenesis, and VEGF, having a dual effect on the tumor cells as well as on the tumor vasculature.Aim: We present a case with hyperthyroidism, as adverse effect of the therapy with sorafenib, but with no markers of thyroid autoimmuni...